Jeremiah 17:5-6
Thus says the Lord, “Cursed is the man who trusts in and relies on mankind, making flesh his strength, and whose mind and heart turn away from the Lord. For he will be like a shrub in the desert and shall not see prosperity when it comes but shall live in the rocky places of the wilderness, in an uninhabited salt land.”

That sounds bleak, but people do it. When people make themselves into a God and no longer rely on and trust in God, they enter a desert in their spirits. No purpose for life exists, and fulfilling the desires of the flesh is the only reason to live. Yet, personal satisfaction will never come to them.