Ephesians 6:18

With all prayer and petition pray (with specific requests) at all times (on every occasion and every season) in the Spirit, and with this in view, stay alert with all perseverance and petition (interceding in prayer) for all God’s people. 

Prayer is how God makes a difference here on earth. We intercede on behalf of people making requests to God. We send out the SOS to God, and God sends His angels to intercede. Prayer is not the last resort but the first line of defense.