Hosea 4:6

My people are destroyed for lack of knowledge (of My law, where I reveal My will). Because you (the priestly nation) have rejected knowledge, I will also reject you from being My priest. Since you have forgotten the law of your God, I will also forget your children.

The pursuit of knowledge of God and His will for our lives leads to happiness. When we reject God and knowledge, we limit our ability to make wise and fulfilling choices. We make decisions that lead to temporary satisfaction based on the hope of finding meaning. A life without Jesus and the Holy Spirit is a life with an unsatisfied void.