Luke 21:10-11

Then Jesus told them, “Nation will rise against nation and kingdom against kingdom. There will be violent earthquakes, and in various places famines and (deadly and devastating) pestilence (plagues, epidemics); and there will be terrible sights and great signs from heaven.

Jesus tells us beforehand what the sign of the end times will be.  The Bible itself warns us that an end is coming and to expect it.  However, we are not to fear but prepare ourselves in the word to reach the unsaved and lost.  We are not to let our hearts shrink back but become bold in proclaiming the good news of the Lord.